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Evolution of the NCCN Guidelines for Kidney Cancer -Tian Zhang

11/21/2018

Tian Zhang and Charles Ryan highlight recent updates in the NCCN treatment guidelines for kidney cancer resulting from data leading to changes in treatment options. Incorporation of initial diagnosis, disease biology, risk category, and clinical factors assist with selecting the most appropriate therapy for these patients.

Epidemiology of Renal Cell Carcinoma

11/20/2018

Despite the improvement in renal cell carcinoma (RCC) diagnosis and management observed during the last 2 decades, RCC remains one of the most lethal urological malignancies. With the expansion of routine imaging for many disorders, an increasing number of patients who harbour RCC are identified incidentally.

A State of Flux for Kidney Cancer

11/19/2018

A State of Flux for Kidney Cancer

Scientists identify potential new treatment strategy for kidney cancer

11/14/2018

Researchers have provided new insight on the mechanisms behind the development of clear cell Renal Cell Carcinoma (ccRCC), according to new findings published in eLife.

Clinical Trial Saves Life of Stage 4 Kidney Cancer Patient

11/14/2018

Dallas journalist Robert Wilonsky beat the odds with help from the team at UT Southwestern.

The 11 most common cancers in the U.S.

11/14/2018

Kidney cancer is one of the most common cancers in the U.S. Men are twice as likely as women to be diagnosed with kidney cancer, according to the ACS. Men's increased exposure to cancer-causing chemicals in the workplace and increased likelihood of smoking may partly explain this gap. For all people, though, the symptoms may include blood in the urine, low back pain on one side of the body that's not linked to an injury, a lump in the lower back, fatigue, appetite loss, unexplained weight loss, and more.

Adjuvant sunitinib in patients with high-risk renal cell carcinoma: safety, therapy management, and patient-reported outcomes in the S-TRAC trial

11/14/2018

Adjuvant sunitinib has significantly improved disease-free survival versus placebo in patients with renal cell carcinoma at high risk of recurrence post-nephrectomy.

CIP2A Promotes Proliferation, Invasion and Chemoresistance to Cisplatin in Renal Cell Carcinoma

11/14/2018

CIP2A is a well-known oncoprotein whose expression is elevated in multiple human solid tumor types. However, its role in renal cell carcinoma (RCC) development is poorly understood.

Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma

11/14/2018

mTOR inhibitors are frequently used in the treatment of metastatic renal cell cancer (mRCC). mTOR regulates cell growth, proliferation, angiogenesis, and survival, and additionally plays an important role in immune regulation. Since mTOR inhibitors were shown to benefit immunosuppressive regulatory T-cell (Treg) expansion, this might suppress antitumor immune responses. Metronomic cyclophosphamide (CTX) was shown to selectively deplete Tregs.

Trials Presented at ESMO 2018

11/14/2018

In patients with previously untreated advanced renal cell carcinoma (RCC) whose tumors were positive for the PD-L1 checkpoint, a combination of the checkpoint inhibitor avelumab and the tyrosine kinase inhibitor (TKI) axitinib increased the median PFS from 8.4 months to 13.8 months when compared with the TKI sunitinib (HR 0.69; P=0.0001).

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