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A 79-year-old female with renal cell carcinoma (RCC) presents with low back pain, low-grade fever, and weight loss. Laboratory tests, computed tomography, and immunohistochemical analysis are described; images provided.
A 26-year-old female at 14 weeks gestation presents with a complex cystic renal mass. Analysis of histology, immunohistochemistry, cytogenetics, and fluorescence in situ hybridisation are described; images provided.
The RCC market has recently attracted significant investments in research and development from big pharma, specialty pharma, and biotechnology companies.
Reduction of transforming growth factor- type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.
Composite renal cell carcinoma with clear cell renal cell carcinomatous and carcinoid tumoral elements: A first case report - Abstract.
To assess the accuracy of renal biopsy for predicting the final nuclear grade and histologic subtype. Small renal masses can be safely observed in select patients who are poor surgical candidates. Renal biopsy may help identify patients who are candidates for observation.
Van Andel Research Institute (VARI) researchers have found a way to reverse resistance to sunitinib, a treatment that is currently the first line of defense against clear cell renal cell carcinoma (ccRCC), a deadly form of kidney cancer. Most patients who show a positive response to sunitinib develop a resistance to the drug after one year of treatment.
With the advent of the new targeted therapies there has been a complete shift in paradigm. Treatment options for patients with advanced disease have improved dramatically; until recently there was limited choice and therapies were poorly tolerated, with relatively low response rates. Patients now face multiple options with improved safety and efficacy, and there are plenty of further therapies in the pipeline. The overall prognosis has changed for these patients and survival is now much longer.
Contrary to claims made by some Democratic detractors, detailed GOP proposals, and a bipartisan bill with several GOP cosponsors, do exist.
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