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Pfizer Inc's (PFE.N: Quote, Profile, Research) experimental drug axitinib has shown promise for treating patients with advanced kidney cancer, slowing the disease for six months or more in some cases, according to a study published on Tuesday. Source: Reuters, Pfizer Inc.
EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of results for its cell cycle inhibitor, MKC-1, in preclinical renal cell carcinoma (RCC) models. The results were presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco, California. Source: EntreMed, Inc
Exelixis, Inc. today reported encouraging data from an ongoing phase 2 trial of XL880, an inhibitor of MET and VEGFR2 kinases, in patients with papillary renal cell carcinoma (PRC). Of 19 patients with measurable disease evaluable for tumor responses, 15 (79%) have had a decrease in tumor size (4-33%), including one patient with a partial response. All 19 evaluable patients with at least one post-baseline tumor assessment have had stable disease for at least three months, including 12 patients with stable disease for six months to 15+ months. Results of preliminary analyses of plasma biomarkers and tumor samples are consistent with inhibition of angiogenesis and proliferation and an increase in apoptosis. Data were presented today in a poster session (Abstract #B249) at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, which is being held October 22-26, 2007 in San Francisco. Source: PRNewswire-FirstCall
Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice
Intradigm Corporation, a leading developer of targeted, systemic RNA interference (RNAi) therapeutics, today announced study results that demonstrated the company's TargeTran(TM) delivery system is capable of delivering vascular endothelial growth factor (VEGF) targeted small interfering RNAs (siRNAs) that suppress tumor-induced angiogenesis by silencing target gene expression in mice. The study findings support the preclinical development of ICS-283 a nanoparticle-based compound comprised of siRNAs that target both VEGF and its main receptor. Complete study findings were presented by Intradigm scientists today at the 2007 AACR- NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Source: PRNewswire
Results of RTA 402 Phase I Cancer Trial Presented at AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference
Reata Pharmaceuticals, Inc. announced today the presentation of results from a Phase I cancer trial of its lead Antioxidant Inflammation Modulator (AIM), RTA 402, in a poster session at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference in San Francisco, CA. A first-in-class targeted therapy, RTA 402 inhibits the activity of two transcription factors, NF-kappa B and STAT3, that play a central role in cancer progression, metastasis, and resistance to therapy. Source: Reata Pharmaceuticals, Inc.
Studies presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics demonstrate the flexibility of targeted therapy techniques, where new drugs can be developed and tested in human trials more quickly and safely than ever before. Among the studies presented include a pair of reports on two separate novel insulin-like growth factor receptor enzyme inhibitors, both currently involved in solid tumor clinical trials. In addition, researchers will be offering details on two Phase II trials involving already-approved drugs in new applications: sunitinib in a form of liver cancer and sorafenib, combined with the cell-signaling molecule IL-21, in metastatic renal cancer. Source: HuliQ.com
ZymoGenetics, Inc. today presented positive Phase 1 interim data from a Phase 1/2 trial of Interleukin 21 (IL-21) in combination with Nexavar(R) (sorafenib) in patients with renal cell cancer. Preliminary data from the Phase 1 trial suggests that the combination of IL-21 and sorafenib is well tolerated, with a toxicity profile similar to known toxicities of each agent alone. This combination therapy has also shown promising anti-tumor activity. Source: www.zymogenetics.com/
THE NHS in the North West failed to spend almost £200m last year yet hospitals in Merseyside are still making cuts and patients are still being denied treatment. Source: Liverpool Daily Post
ZymoGenetics, Inc. today presented positive Phase 1 interim data from a Phase 1/2 trial of Interleukin 21 (IL-21) in combination with Nexavar(R) (sorafenib) in patients with renal cell cancer. Preliminary data from the Phase 1 trial suggests that the combination of IL-21 and sorafenib is well tolerated, with a toxicity profile similar to known toxicities of each agent alone. This combination therapy has also shown promising anti-tumor activity. Source: PRNewswire-FirstCall
Cleveland BioLabs, Inc. (NASDAQ: CBLI) (BOST: CBLI) today announced that the Company is scheduled to present at the Rodman & Renshaw 9th Annual Global Healthcare Conference, on November 5-7, in New York City. Cleveland BioLabs currently has two lead compounds in late stages of development. Curaxin CBLC102 is an orally administered small molecule designed to kill tumor cells by simultaneously targeting two key regulators of apoptosis. The Company has an ongoing Phase II trial with CBLC102 in hormone refractory prostate cancer and will begin a second Phase II trial in Renal Cell Carcinoma in late 2007. Source: The Global Consulting Group
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