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Acceleron Initiates Phase 2 Study of Dalantercept (ACE-041) to Treat Patients with Metastatic Renal Cell Carcinoma

02/06/2013

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, announced the initiation of a phase 2 study of dalantercept, a novel angiogenesis inhibitor that targets the activin receptor-like kinase 1 (ALK1) pathway.

Activity of single-agent bevacizumab in patients with metastatic renal cell carcinoma

02/05/2013

The activity of systemic agents after progression when using vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibition (TKI) and mammalian target of rapamycin (mTOR) inhibition in patients with metastatic renal cell carcinoma (mRCC) is poorly characterized.

Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival

02/05/2013

CUB domain-containing protein 1 (CDCP1) is a transmembrane protein that is highly expressed in stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer. CDCP1 promotes cancer cell metastasis...

13-year-old tuberous sclerosis patient with renal cell carcinoma

02/05/2013

We report a 13-year-old white girl with epilepsy and hypopigmented skin lesions...

Cancer's caregiver crisis of control

02/05/2013

Life experience doesn't prepare you for cancer caregiving.

23andMe: Innovation in Metastatic Cancer Researc

02/05/2013

Genetics can sometimes explain why some people respond well to a drug whereas others may experience serious side effects. The InVite Study is a collaborative effort between 23andMe and Genentech to learn more about how genes influence response to bevacizumab (also known as Avastin®) in the treatment of locally recurrent or metastatic breast cancer, metastatic colorectal cancer, metastatic non-squamous non-small cell lung cancer, recurrent glioblastoma, or metastatic renal cell carcinoma.

Today is World Cancer Day!

02/04/2013

Cancer is a leading cause of death worldwide. In 2008, it was the cause of 7.6 million deaths globally, and it is estimated that a third of those deaths could have been avoidable with greater prevention, early detection and existing treatments.

Shrive Named 2013 Uplifting Athletes Rare Disease Champion Award winner.

02/01/2013

Shrive was one of seven finalists this year and becomes the fifth recipient of the award.

David's Clinical Trial Experience

02/01/2013

David participated in a Phase 2 clinical study that evaluated a personalized cancer immunotherapy in combination with a standard targeted drug therapy, sunitinib.

NCI Ends Brash Foray Into the News Business

02/01/2013

Emails Tell the Story of the NCI Cancer Bulletin

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