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A randomized double-blind cross-over patient preference study of pazopanib versus sunitinib in treatment-naive locally advanced or metastatic renal cell carcinoma

06/09/2010

Angiogenesis inhibitors have demonstrated significant clinical efficacy in mRCC. Pazopanib and sunitinib are both oral tyrosine kinase inhibitors primarily of VEGFR (-1, -2, and -3), PDGFR (-a and -b) and c-Kit. Pazopanib has a more selective kinase specificity profile compared to sunitinib and has demonstrated low rates of fatigue, hand foot syndrome and mucositis/stomatitis. There is an ongoing phase III head to head study of pazopanib vs. sunitinib in treatment naïve mRCC patients (pts). The outcomes of cancer therapy are traditionally evaluated using RECIST response and survival criteria. There is increasing emphasis on assessment of health related quality of life (HRQoL) particularly relevant to tolerability of agents. However, HRQoL questionnaires might not reflect the pt preference. Studies have shown an association between toxicity/intolerability and a response on HRQoL, suggesting that pt preference is a legitimate and useful endpoint.

Kidney Cancer Association receives Donor Recognition Award

06/08/2010

Kidney Cancer Association Honored For Commitment To Research

06/08/2010

No charity of our size with a specific focus on the elimination of death and suffering from kidney cancer has funded a greater number of research projects. This week, the ASCO Cancer Foundation presented us with an award to mark this commitment.

Kidney Cancer News from ASCO

06/07/2010

Get the latest news about kidney cancer from the 2010 Annual Meeting of the American Society of Clinical Oncology, in Chicago, Illinois.

Evolving Standards of Care in Advanced Renal Cell Carcinoma

06/07/2010

Systemic Therapies in Advanced Renal Cell Cancer: Current Status by Christopher W. Ryan, M.D.

New data supporting AS1413 and AS1411

06/07/2010

"We're delighted to share a wealth of new data on AS1413 and AS1411 at the ASCO meeting. Both drugs are approaching important milestones, with phase III data on AS1413 and phase IIb data on AS1411 due in the next 12 months. The latest findings provide further evidence of the unique potential of these novel approaches to cancer therapy."

Consumption of filtered and boiled coffee and the risk of incident cancer: A prospective cohort study

06/07/2010

These findings demonstrate, for the first time, the potential relevance of brewing method in investigations of coffee consumption and cancer risk.

Data On Several Investigational Cancer Treatments

06/07/2010

Abbott scientists and independent researchers will highlight the latest clinical trial data on four of Abbott's investigational oncology compounds at this year's American Society of Clinical Oncology (ASCO) Annual Meeting.

Antisoma announces presentation at ASCO of new data supporting AS1413 and AS1411

06/06/2010

Glyn Edwards, CEO of Antisoma, said: "We're delighted to share a wealth of new data on AS1413 and AS1411 at the ASCO meeting. Both drugs are approaching important milestones, with phase III data on AS1413 and phase IIb data on AS1411 due in the next 12 months. The latest findings provide further evidence of the unique potential of these novel approaches to cancer therapy."

2010 ASCO Annual Meeting Abstracts

06/06/2010

Abstracts published in the Annual Meeting Proceedings: late-Breaking Abstracts, and Clinical Review Abstracts will be available at 12:00 PM EDT on the date of their presentation at the 2010 ASCO Annual Meeting.

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NeonCRM by Neon One