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Researchers evaluating immunotherapy approaches for treating metastatic kidney, prostate, bladder cancers

12/14/2013

Researchers at the Roswell Park Cancer Institute (RPCI) Center for Immunotherapy are enrolling patients in three different clinical trials of novel immunotherapy approaches for treating genitourinary cancers.

Chromophobe renal cell carcinoma with concomitant sarcomatoid transformation

12/14/2013

Chromophobe renal cell carcinoma is the third most common form of adult renal epithelial neoplasm. A sarcomatoid component occurs in approximately 8% of all chromophobe renal cell carcinoma cases, while metaplastic bone formation is extremely rare.

PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib-Treated Patients

12/12/2013

A modeling framework relating exposure, biomarkers (vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor (sVEGFR)-2, -3, soluble stem cell factor receptor (sKIT)), and tumor growth to overall survival (OS) was extended to include adverse effects (myelosuppression, hypertension, fatigue, and hand–foot syndrome (HFS).

Laser therapy may boost vaccine potency

12/12/2013

Visit spurs Mass. General doctor to pursue treatment

Early tumor shrinkage predicts targeted therapy efficacy

12/12/2013

Early tumor shrinkage in patients with metastatic renal cell carcinoma (mRCC) following vascular endothelial growth factor (VEGF)-targeted therapy may herald good long-term survival, research shows.

Low sodium levels linked to poor targeted therapy outcomes

12/12/2013

Low serum sodium levels in patients receiving targeted therapy for metastatic renal cell carcinoma (mRCC) may signal a poor outcome, study findings indicate.

First-Line Inlyta Active in Metastatic Kidney Cancer

12/12/2013

First-line therapy with Inlyta® (axitinib) demonstrated clinical activity in metastatic renal cell carcinoma, according to the results of a study published in The Lancet Oncology.

Findings on Carcinomas Reported by Investigators at University of Texas

12/12/2013

"We prospectively assessed the efficacy and safety of axitinib dose titration in previously untreated patients with metastatic renal-cell carcinoma. In this randomised, double-blind, multicentre, phase 2 study, patients were enrolled from 49 hospitals and outpatient clinics in the Czech Republic, Germany, Japan, Russia, Spain, and USA. Patients with treatment-naive metastatic renal-cell carcinoma received axitinib 5 mg twice daily during a 4 week lead-in period..."

Predicting outcome for high-dose IL-2 therapy

12/11/2013

One of the most potent forms of immunotherapy for patients with metastatic melanoma and renal cell carcinoma is high-dose (HD) bolus IL-2 therapy. Approximately 15% of patients respond to HD IL-2 therapy, with almost 5% going into complete remission;..

Clinical heterogeneity of Xp11 translocation renal cell carcinoma

12/09/2013

Impact of fusion subtype, age, and stage

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