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Phase I/II study of adoptive transfer of T cells in combination with zoledronic acid

03/15/2012

Human Vγ2 Vδ2-bearing T cells have recently received much attention in cancer immunotherapy. In this study, we conducted a phase I/II clinical trial of the adoptive transfer of γδ T cells to patients with advanced renal cell carcinoma.

Metabolism, Excretion, and Pharmacokinetics of Oral Brivanib in Patients with Advanced or Metastatic Solid Tumors

03/15/2012

To evaluate the pharmacokinetics, mass balance, metabolism, routes and extent of elimination, and safety of a single oral dose of [(14)C]-labeled brivanib alaninate and the safety and tolerability of brivanib after multiple doses in patients with advanced or metastatic solid tumors.

Systemic IL-12 Administration Alters Hepatic Dendritic Cell Stimulation Capabilities

03/15/2012

The liver is an immunologically unique organ containing tolerogenic dendritic cells (DC) that maintain an immunosuppressive microenvironment. Although systemic IL-12 administration can improve responses to tumors, the effects of IL-12-based treatments on DC, in particular hepatic DC, remain incompletely understood.

India uses arm-twist rule for cancer drug

03/14/2012

New Delhi, March 12: India has for the first time exercised its legal right to arm-twist pharmaceutical companies to make available expensive, patented medicines at a lower cost, allowing the generic manufacture of a cancer drug owned by a foreign company.

Kidney Cancer Association requests call to Congress

03/14/2012

“We've made it easy for people to join this effort using a simple online tool,” says KCA Chief Executive, Bill Bro, a 22-year kidney cancer survivor.

Outcome predictors of Gamma Knife radiosurgery for RCC

03/14/2012

To evaluate the role of stereotactic radiosurgery (SRS) in the management of brain metastases from renal cell carcinoma.

Tumor Disappearance Following Radiation

03/13/2012

The phenomenon reported by the researchers, known as the abscopal effect, occurs when localized radiation therapy delivered to a single tumor in a patient with advanced disease results in tumor disappearance outside of the irradiated area. Though the abscopal effect is extremely rare, it has been described in several cancers including melanoma, lymphoma, and kidney cancer.

Three 'targeted' cancer drugs raise fatal side effect risk

03/10/2012

Treatment with three relatively new "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects.

Is Cancer Outwitting Personalized Medicine?

03/08/2012

Discovery of many genetic mutations within one cell may dash hopes for targeted treatments.

Cancer vaccine – IMA901/IMA910

03/07/2012

Therapeutic vaccines may prove both effective and directed as cancer treatments. One such product, being developed by Immatics Biotechnologies, is based on a selection of naturally presented tumour-associated peptides. Two versions are currently in the clinic – IMA901 for renal cell carcinoma...

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