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Generic Sutent On Horizon?

05/14/2010

Mylan Inc. (MYL) has applied for U.S. regulatory approval to sell a generic version of Pfizer Inc.'s (PFE) Sutent cancer pill by challenging several patents on the drug.

When Kidney Cancer Hits the Vena Cava

05/14/2010

It’s a nasty-looking chunk of cancer, a plug of renal cell carcinoma that sometimes finds its way into the inferior vena cava. Because of its location in the body’s largest vein and its potential threat to the heart and brain, this tumor thrombus is serious indeed.

Treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma is associated with drug-induced hyperparathyroidism

05/14/2010

Multi-targeted tyrosine kinase inhibitors (MTKIs) are the standard in the treatment of metastatic renal cell carcinoma (mRCC). In spite their clinical activity, interaction with physiological functions has been shown. Here, we report on alterations of the bone mineral metabolism in patients with mRCC treated with MTKIs.

Review of the activity of sorafenib, sunitinib and bevacizumab

05/14/2010

Renal cell carcinoma accounts for approximately 3% of all human malignancies. The use of cytokines in metastatic stage of disease has been the standard until last decades, presenting partial and short duration responses. Research on angiogenesis in renal carcinoma has brought important advances to understand tumor biology and to allow us development of new antiangiogenic drugs.

IMBiotechnologies Receives FDA Clearance to Market Occlusin(R) 500 Biodegradable Microspheres in the U.S.

05/12/2010

OCL 500 is a microspherical agent in development for the treatment of highly vascularised tumours, including hepatocellular carcinoma (HCC; liver cancer), renal cell carcinoma (RCC; kidney cancer) and uterine fibroids.

Temsirolimus as Treatment for Advanced Renal Cell Carcinoma

05/12/2010

This report summarizes the U.S. Food and Drug Administration (FDA)'s approval of temsirolimus (Torisel®), on May 30, 2007, for the treatment of advanced renal cell carcinoma (RCC). Information provided includes regulatory history, study design, study results, and literature review.

Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent

05/12/2010

In the present study, the activity and protein and mRNA expression of these glycoproteins were analysed in a subset of clear-cell (CCRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytomas (RO).

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

05/12/2010

Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes that mediate cell survival, proliferation, and angiogenesis and is aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC). We examined whether it could be a novel therapeutic target for RCC by using the STAT3 inhibitor WP1066.

CO2 Angiography in Interventional Oncology

05/12/2010

CO2 angiography not only helps prevent undesired complications, but it can also assist in the performance of interventional oncologic procedures

Kidney Removal: No Help For Elderly Cancer Patients

05/12/2010

Patients aged 75 years or older who have confined kidney tumors do not live longer if they have their entire kidney removed.

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