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Hyaluronan and hyaluronidase in genitourinary tumors

09/21/2010

Many studies have demonstrated the strong correlation between HA accumulation and presence of malignancy in numerous solid tumor types, including genitourinary cancers.

Discovery May Lead to More Potent Drug Combinations

09/08/2010

"The results might suggest new ways to combine AurA inhibitors with other drugs to boost their activity," says Erica A. Golemis, Ph.D.

Addition of Sutent to Tarceva Does Not Prolong Survival

09/07/2010

Sutent is an oral targeted agent that works by inhibiting multiple biologic pathways involved in the growth, replication, and spread of cancer cells. It has been shown to be effective in the treatment of selected patients with kidney cancer or gastrointestinal stromal tumors, and is also being evaluated in the treatment of other types of cancer.

Postcard From the NHS

09/04/2010

239 patients died of malnutrition in British hospitals, the latest year for which figures are available . . . the real roots of this tragedy lie in Britain's government-run medical system, which tells us something about what we might expect from ObamaCare in the years ahead.

Long-term survival of patients with sarcomatoid renal cell cancer treated with chemotherapy

09/01/2010

We now report long-term survival of 4 patients with stage IV sarcomatoid renal cell carcinoma treated with this regimen . . .

Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib

09/01/2010

The patient had stable disease after 8 weeks (two cycles) of everolimus that was maintained until 28 months of therapy, at which time the patient had achieved a partial response. This case illustrates the potential for patients with metastatic renal cell carcinoma, a malignancy with historically poor prognosis, to derive long-term benefit from everolimus when used in a manner consistent with its approved indication (after TKI therapy with sunitinib or sorafenib).

Is it possible to detect early symptoms of Wilms' tumor?

09/01/2010

Wilms' tumor is a rare childhood form of kidney cancer also known as nephroblastoma. Only about five in a million American children will be diagnosed with Wilms' tumor each year, mostly around age 3, but 10% of those children will die within five years of their diagnosis. For this reason, as with all cancers, it is important to catch the disease and begin treatment as early as possible.

A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer

09/01/2010

Serum interleukin (IL)-6 levels correlate with disease outcomes in renal cell carcinoma (RCC) patients. Siltuximab, a chimeric, murine-human mAb against IL-6, was evaluated in a three-part phase I/II study in patients with progressive metastatic RCC.

Promise Of Tumor Ablation

08/31/2010

The unprecedented growth and promise of using thermal ablation to target and kill cancer is the subject of the Journal of Vascular and Interventional Radiology's August supplement, "Thermal Ablation 2010: At the Crossroads of Past Success, Current Goals and Future Technology."

Sequential use of targeted agents in the treatment of renal cell carcinoma

08/31/2010

The optimal sequence may vary among patients to accommodate comorbid conditions or different disease stages.

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