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U.S. scientists at the Mayo and Cleveland clinics say they've found blood flow interruption during kidney cancer surgery can lead to chronic kidney disease.
The Example of Sunitinib for First-Line Treatment of Metastatic Renal Cell Carcinoma
Local Relay for Life raises $21,000 for cancer research, education and patient support
The European Commission has granted a conditional marketing authorisation for a GlaxoSmithKline drug that treats the most common form of kidney cancer.
The widely used cancer drug bevacizumab (Avastin) is associated with a more than fourfold increased risk of severe urinary protein loss, a new review finds.
Immatics announces Phase II Results with its Therapeutic Cancer Vaccine IMA901 in Patients with Advanced Renal Cell Carcinoma
Results of multi-center phase II trial highlight the promise of cancer vaccines in showing strong signal for improved survival with significant correlation of immune response and survival and excellent safety profile.
AVEO Pharmaceuticals Tivozanib Demonstrates Progression-Free Survival of 14.8 Months in Subgroup of Patients with Advanced Kidney Cancer; Extended Duration of Treatment Continues to Highlight Favorab
AVEO Pharmaceuticals, Inc. (NASDAQ: AVEO), a biopharmaceutical company focused on discovering, developing and commercializing cancer therapeutics, today announced data from a subgroup analysis of a Phase 2 randomized discontinuation trial showing that the median progression-free survival (PFS) achieved by patients with advanced clear cell renal cell carcinoma (RCC) who had undergone a prior nephrectomy was 14.8 months.
Argos Therapeutics Presents Positive Phase 2 Data for Arcelis Dendritic Cell-based Immunotherapy in Advanced RCC at ASCO
Argos Therapeutics today announced the presentation of positive interim data from a Phase 2 trial that evaluated the clinical activity, safety and immune response of AGS-003 treatment, given in combination with sunitinib, in patients with newly diagnosed advanced renal cell carcinoma (RCC).
Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer
Secreted frizzled-related protein-5 (sFRP-5) has been identified as 1 of the secreted antagonists that bind Wnt protein. However, the functional significance of sFRP-5 in renal cell cancer (RCC) has not been reported. We hypothesized that sFRP-5 may be epigenetically downregulated through DNA methylation and histone modification and function as a tumor suppressor gene in RCC. Using tissue microarray and real-time RT-PCR, we found that sFRP-5 was significantly downregulated in kidney cancer tissues and cell lines, respectively. DNA bisulfite sequencing of the sFRP-5 promoter region in RCC cell lines showed it to be densely methylated, whereas there was few promoter methylation in normal kidney.
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