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Disease-Specific Survival in De Novo Metastatic Renal Cell Carcinoma in the Cytokine and Targeted Therapy Era
Recent phase III studies of targeted agents for metastatic renal cell carcinoma (mRCC) have generated median survival estimates that far exceed those observed during the cytokine era. However, substantial population-based data does not exist to confirm this trend. We sought to determine whether survival has improved for patients with mRCC diagnosed in the era of targeted therapies, as compared to the era of immunotherapy.
In a 13-1 vote on Thursday, the panel said Aveo had not shown that the drug's benefits outweighed its risks in a well-controlled study, and said a second trial would be needed before the drug, tivozanib, should be approved.
UroGenRA™-Kidney was designed and developed at Cancer Genetics to assist in the diagnosis and treatment selection of kidney cancer.
SonaCare Medical, a global leader in minimally invasive HIFU technologies, announced today that it has partnered with University College London (UCL) to create a HIFU Center of Excellence.
ZEB2 has been reportedly shown to mediate the epithelial-to-mesenchymal transition (EMT) and disease aggressiveness in human tumors. However, the expression status of ZEB2 in renal cell carcinoma (RCC) and ZEB2’s clinicopathologic/prognostic significance are poorly understood.
Researchers at Mayo Clinic’s campus in Florida have discovered a protein that is overly active in every human sample of kidney cancer they examined.
They asked the panel to consider whether a new trial was needed to better assess risk versus benefit, given that other treatments are available.
2 May 2013, Budapest
Streams live 3-4 May from Hungary
This year’s grant recipient of the Kidney Cancer Association (KCA) Eugene P. Schonfeld Research Award is Dr. Eliezer Van Allen, of Dana-Farber Cancer Institute, whose project is titled “Dissecting clinical resistance to PI3K inhibitors in PIK3CA or PTEN-mutant cancers.”
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