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Choueiri Reflects on Recent RCC Advances

07/27/2018

Toni K. Choueiri, MD reflects on recent RCC advances.

Sexual Disorders of Patients With Metastatic Renal Cell Carcinoma (mRCC) Treated With Antiangiogenic Therapies

07/27/2018

Targeted therapies, in particular antiangiogenic therapies (AATs), have become the standard of treatment for metastatic renal cell carcinoma (mRCC). Although common adverse effects like fatigue have been well-established, sexual disorders induced by these treatments, although often reported, have been poorly evaluated.

Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma

07/27/2018

Progesterone receptor membrane component 1 (PGRMC1) and Na+/K+‑ATPase α1 subunit (ATP1A1) are two proteins associated with the clinical prognosis of renal cell carcinoma (RCC) and RCC cell proliferation. However, the two proteins have been previously studied independently, and their combined influence on the clinical outcome of RCC remains unclear.

mRCC: Cytoreductive Nephrectomy in the Modern Era

07/26/2018

Walter Stadler, M.D., who is on our medical steering committee, is one of the panelists in this video.

Patients With Early Kidney Cancer Benefit From Robotic Partial Nephrectomy

07/26/2018

A comprehensive study by the Keck School of Medicine of USC, which has found that robotic partial nephrectomy offers significantly better patient outcomes.

Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma

07/25/2018

Clear cell renal cell carcinoma (ccRCC) is the main subtype of malignant kidney cancer. Long non‑coding RNA (lncRNA) serves a key role in predicting survival in patients with cancer.

Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis

07/25/2018

Treatment of patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease (ESRD) on dialysis poses a therapeutic challenge, particularly as this patient group was excluded from the pivotal clinical trials. In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis.

Poorer RCC outcomes with incidental upstaging after partial nephrectomy

07/25/2018

Patients with incidental pathologic T3a (pT3a) upstaging after partial nephrectomy (PN) have significantly reduced recurrence-free survival (RFS) and cancer-specific survival (CSS) when compared to patients whose disease isn't upstages from pT1a-b.

Good results seen with laparoscopic partial nephrectomy following selective embolization of tumor

07/25/2018

The short-term oncological and functional outcomes for partial nephrectomy are comparable for laparoscopic partial nephrectomy following selective embolization of tumor (LPNE) in a hybrid operating room and robot-assisted partial nephrectomy (RAPN). A longer follow-up and a larger cohort of patients would be necessary to verify the benefits of LPNE, which appears to be a very interesting alternative to RAPN.

Rise in Localized High-Risk RCC Reported

07/24/2018

Over a 25-year period, the proportion of patients with high-risk clinical T1 tumors increased by nearly 20 percent and clinical tumor size decreased from 8.4 to 6.2 cm, an Italian study found.

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