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Thalidomide is now FDA-approved for the treatment of multiple myeloma. It has also been used to treat myelofibrosis, Kaposi sarcoma, and renal cell cancer along with the pain of leprosy. Many more uses for thalidomide are under study. Thalidomide is dangerous only when used in the wrong patients.
Benzene has been connected to a rare form of kidney cancer in two separate studies, one involving tank truck drivers, and the other involving seamen on tanker vessels, both carrying benzene-laden chemicals.
The authors report the case of a patient who underwent treatment for renal cell carcinoma and noted additional benefit by improvement in his psoriatic skin lesions.
The present study aimed to assess the clinicopathological characteristics and the prognosis of renal cell carcinoma (RCC) in children.
A new cutting-edge cancer centre dedicated to robotic surgery, cancer imaging and drug discovery is launched today, putting London at the forefront of cancer research.
TopAbstracts in Renal Cancer are the abstracts most highly rated/most read by nearly 300,000 physicians who received a Doctor's Guide newsletter or visited a website Powered by Doctor's Guide in the past 14 days. Over 2000 peer-reviewed journals are covered by TopAbstracts.
Frequent Dose Interruptions are Required for Patients Receiving Oral Kinase Inhibitor Therapy for Advanced Renal Cell Carcinoma
The experience suggests that the first 4 weeks of treatment is the most likely timeframe within which drug reactions occur. Therefore, careful monitoring and possibly additional clinical visits are warranted during this time period. Although a significant percentage of patients require dose modification, many can be restarted and titrated up to the targeted dose.
Vining says the specialty of radiology needs better practice guidelines on how to handle these. About 10 percent of CT-screened patients will have a significant extracolonic finding, such as lung or kidney cancer. The majority of extracolonic findings, however, are benign entities such as kidney and gall stones or benign tumors.
Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Consistent with this function, the authors observed loss or a decrease of H3K36me3 in 7 out of the 10 cRCC cell lines. Identification of missense mutations in 2 out of 10 primary cRCC tumor samples added support to the involvement of loss of SETD2 function in the development of cRCC tumors.
Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin
Recommended phase II doses of this combination are sorafenib 400 mg twice daily and tanespimycin 400 mg/m2 on days 1, 8 and 15 every 28 days. Clinical and pharmacodynamic activity was observed in kidney cancer and melanoma.
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