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Novel Therapies for Metastatic Renal Cell Carcinoma

03/07/2012

With six agents approved for metastatic renal cell carcinoma (mRCC) within the past 5 years, there has undoubtedly been progress in treating this disease. However, the goal of cure remains elusive, and the agents nearest approval (i.e., axitinib and tivozanib) abide by the same paradigm as existing drugs (i.e., inhibition of VEGF or mTOR signaling).

Simple Enucleation Versus Radical Nephrectomy

03/06/2012

The aim of the present study is to compare the oncologic outcomes after TE and RN in pT1 RCCs.

PAX-2 Is a Helpful Marker

03/06/2012

To evaluate the role of PAX-2, a renal tubular cell transcription factor, in the diagnosis of metastatic RCC.

Pharmacological Inhibition of Cyclin Dependent Kinases Causes p53 Dependent Apoptosis in Renal Cell Carcinoma

03/06/2012

We evaluated the effect of roscovitine (Sigma-Aldrich®), a pharmacological inhibitor of cyclin dependent kinase, on renal cell carcinoma cell lines in vitro.

The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma

03/06/2012

Inhibitors of TORC1 have been shown to be active in patients with metastatic renal cell carcinoma (RCC).

March is Global Kidney Cancer Awareness Month

03/04/2012

“Of course,” Bro says, “with growth comes the risk of opportunism. KCA is working hard to assure that patients are served by organizations that subscribe to the highest ethical standards. We’ve started a new web page where the public can report suspicious behavior.”

Single-cell sequencing leads to a new era of cancer research

03/04/2012

Researchers applied their new single-cell sequencing (SCS) method to identify the genetic characteristics of clear cell renal cell carcinoma...

Mechanicsburg Lift for Life to be held Saturday, March 3

03/03/2012

Lift for Life is the signature event of “Uplifting Athletes,” a nonprofit organization created by Penn State Football student-athletes. Their mission is to align college football with rare diseases and recognize them as a national priority. Mechanicsburg Senior High School students have joined the effort of the Penn State chapter to raise money and promote awareness for the prevention, diagnosis, and treatment of kidney cancer. This rare disease has directly affected several staff members at Mechanicsburg Area Senior High in recent years. Don Shirley, the inspiration behind the Lift for Life initiative, lost his decade long battle with kidney cancer on October 17, 2005. He was 55 years old. His death has strengthened our resolve to continue his work. Compared to more recognized diseases, there is very limited funding for kidney cancer. All proceeds raised by the Lift for Life event benefit the Kidney Cancer Association. Since 2003, over $400,000 has been raised for this cause, and as a result, a number of new breakthroughs have been developed in the fight against this deadly disease.

Long-term safety of sorafenib

03/01/2012

A retrospective subgroup analysis was performed to evaluate the efficacy and safety of sorafenib in patients in TARGET who received treatment for >1year.

Thyroid dysfunction in patients with advanced RCC

03/01/2012

Several studies have reported the substantial prevalence of sunitinib-induced thyroid dysfunction.

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