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B7-H1 connection of innate and adaptive immunity against tumor dormancy
06/13/2008
Dormant leukemia cells are selected to express B7-H1 and become resistant to T cells, whereas their susceptibility to NK cells remains intact. In contrast, NK cells expressing B7-H1 stimulate T-cell activation, which in turn keeps NK cells active. As a consequence, NK cells become the major player in eradicating dormant leukemia cells. More